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Add:Room 308, North Wanke Creative Quarter, No2000, Dongming Road, Pudong New District, Shanghai, China

Tel:86-21-66531378

Fax:86-21-66531373

Email:sales@ingredient4health.com

Web:www.ingredient4health.com

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Pharmaceutical excipient L-HPC (Low-substituted Hydroxypropyl Cellulose) 9004-65-3 disintegrant

1、Product Introduction 2.Product Application This product is mainly used as a tablet disintegrating agent and a binder. The characteristic is: easy to press molding, strong applicability, especially for tablets that are not easy molding, plasticity and brittleness. Added to the product can...

Product Details

1、Product Introduction


     The generic name

Hydroxypropylcellulose (low substituted)

Abbreviation

L-HPC

IUPAC name

Cellulose, 2 - hydroxypropyl ether (low substituted)

Meet the standards

CP(Chinese Pharmacopoeia)
     USPNF(U.S. National Formulary)
     JP(Japanese Pharmacopoeia)

2.Product Application
This product is mainly used as a tablet disintegrating agent and a binder. The characteristic is: easy to press molding, strong applicability, especially for tablets that are not easy molding, plasticity and brittleness. Added to the product can significantly improve the hardness of the tablet and the appearance of brightness, Moreover makes the tablet disintegrating rapidly, even if the hardness of the tablet reaches 13kg, disintegrating need only ten minutes, therefore improving the tablet intrinsicquality, so improve efficacy; Using this product prepared tablets the disintegration is not affected for a long-term preservation.
Used as tabled binder, the wet granulation is generally plus 5-20%, the powder directly tableting the amount of 5-20%; Used as tablet disintegrating agents, the amount of 2-10%, typically 5%, whether within plus or plus, depending on the prescription.
3.Technical Indicators


     Index

Specification

GD-11

GD-21

GD-31

GD-22

GD-32

Application

Direct compression (anti-top bifida)

General
     (Dry mixing, wet granulation)

Pellets by extrusion, drugs stratification

The routine Model (sometimes disintegrating is better)

Particles extruded drug laminated

Content

10.0~12.9%

7.0~9.9%

pH

5.0~7.5

Loss on drying

≤8.0%

Chloride

≤0.20%

Residue on ignition

≤1.0%

Molysite

≤0.010%

Arsenic salt

≤0.0003%

Heavy metals

≤20ppm

4.Product Description
 【Note】This product can react with the alkaline substances,So if the tablet formulationscontaining alkaline substances, the disintegration or dissolution time may be extendedafter a long period of storage.For this,if the Preparation raw material is alkaline substances and prescription contents this goods, the production enterprises should strengthen the stability test, disintegration time and dissolution investigation.
 【Storage】sealed,keep in a dry place.
 【Packing】kraft paper bag lined with polyethylene bag.
 【Net weight】20kg/package

Contact Us
Shanghai Shine High International Trade Co.,Ltd
Add:Room 308,North Wanke Creative quarter,No2000,Dongming Road, Pudong new district,Shanghai, China
Tel:86-21-66531378
Fax:86-21-66531373
Email:sales@ingredient4health.com
Web:http://www.ingredient4health.com/

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